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化工儀器網(wǎng)>產(chǎn)品展廳>生命科學(xué)儀器>組織學(xué)設(shè)備>其它組織學(xué)設(shè)備>uheart,uKNEE biomimx芯片心臟模型關(guān)節(jié)炎軟骨模型

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uheart,uKNEE biomimx芯片心臟模型關(guān)節(jié)炎軟骨模型

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世聯(lián)博研(北京)科技有限公司(Bio Excellence International Tech Co.,Ltd)簡稱為世聯(lián)博研。世聯(lián)博研是一家集進口科研儀器代理銷售以及實驗技術(shù)服務(wù)于一體的技術(shù)公司。世聯(lián)博研專注生物力學(xué)和3D生物打印前沿科研設(shè)備代理銷售及科研實驗項目合作服務(wù),內(nèi)容涵蓋了血管力學(xué)生物學(xué)、生物力學(xué)建模仿真與應(yīng)用、細胞分子生物力學(xué)、組織修復(fù)生物力學(xué)、骨與關(guān)節(jié)生物力學(xué)、口腔力學(xué)生物學(xué)、眼耳鼻咽喉生物力學(xué)、康復(fù)工程生物力學(xué)、生物材料力學(xué)與仿生學(xué)、人體運動生物力學(xué)等生物力學(xué)研究以及生物材料打印、打印樣品生物力學(xué)性能測試分析的前沿領(lǐng)域科研利器和科研服務(wù)。

世聯(lián)博研的客戶范圍:
科研院所單位、生物醫(yī)學(xué)科研高校、醫(yī)院基礎(chǔ)科研單位等。

世聯(lián)博研公司代理的品牌具有:
1)近10年長期穩(wěn)定的貨源
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3)提供專業(yè)產(chǎn)品培訓(xùn)和銷售培訓(xùn)
4)良好的技術(shù)支持
5)已成交老客戶考證
6)每年新增的貨源。

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應(yīng)用領(lǐng)域 醫(yī)療衛(wèi)生,生物產(chǎn)業(yè)

心臟模型關(guān)節(jié)炎軟骨模型,uheart,uKNEE-現(xiàn)貨

BiomimX offers a broad range of human pathophysiological models on a chip, though to be the next generation in vitro preclinical tools for drug discovery.

uHEART

uHeart is a miniaturized model of a functional  and beating human heart on a chip. uHeart is the ideal platform to screen drug cardiotoxicity as early as possible in the drug discovery pipeline.

Cardiac construct generated from cardiomyocytes derived from human iPSCs

Comparison of cardiac constructs trained with uBeat technology vs a static control

Thanks to BiomimX's technology uBeat, a mechanical training phase resembling the heart beating is applied to uHeart, leading within few days to the generation of a mature human cardiac tissue.

Cardiac construct on drugs

uHeart becomes thus able to respond to drugs as close as the human heart would do, becoming the ideal platform to screen drug cardiotoxicity and anti-arrhythmic drug efficiency. uHeart is indeed able to respond to drugs in a dose-dependent fashion.

uHeart can provide measurement of the key function of the heart to understand changes in heart beating rate, structural toxicity and electrical activities.

uKNEE

uKnee is the first in vitro miniaturized model of a human osteoarthritic (OA) cartilage. uKnee will be a pioneering tool helping to speed up the discovery for anti-OA drugs.

Cartilaginous construct generated from human healthy articular chondrocytes

uKnee is a miniaturized model of a cartilage on chip. Thanks to BiomimX's technology uBeat, a mechanical overload resembling the OA pathological conditions is applied to uKnee, leading within few days to the generation of an OA-like tissue with a phenotype and genotype correlating with OA clinical evidences.

 

uKnee can thus be used to test the efficiency of potential new anti-OA candidates to reverse the pathology, being the first in vitro platform able to replicate OA disease.

uKnee provides measurement of the key conditions of OA, including anabolic-catabolic balance changes, occurrence of inflammation, production of matrix degrading enzymes and changes in key molecular pathways.

CUSTOMIZED MODELS

Our organ-on-chip technolgy is ideal for the generation of most 3D in vitro models. High-throughput and mechanical stimulation offer unique features in drug screening and precision modeling.

3D modelof human mesenchymal stromal cells

We develop healthy and diseased organ models that are tailored to your requirements. Combining your specific biological knowledge and questions with our unique technology uBeat and our expertise in developing miniaturized in vitro models, we will offer you the possibility to develop unique models both for applied drug development and basic research studies on human disease mechanisms or organ developmental processes.



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