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南京科佰生物科技有限公司

中級會員 | 第11年

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產(chǎn)品型號CBP10271

品牌cobioer/科佰生物

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所在地南京市

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產(chǎn)品簡介

供貨周期	現(xiàn)貨	規(guī)格	1ug
貨號	CBP10271	應(yīng)用領(lǐng)域	生物產(chǎn)業(yè)

ERBB2 p.V842I Reference Standard

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CBP10271
Format	Genomic DNA
Description	ERBB2 (HER2) V842I lies within the protein kinase domain of the Erbb2 (Her2) protein (UniProt.org). V842I results in increased Erbb2 (Her2) activity, downstream Mapk pathway activation, and the ability to transform cells in culture (PMID: 23220880), however in another study, V842I results in similar cell proliferation and viability levels as wild-type Erbb2 (Her2), in two different cell lines (PMID: 29533785).

Technical Data
DNA Change	c.2524G>A
AA Change	p.V842I
Mutation type	Substitution - Missense
Zygosity	Heterozygous
Allelic Frequency	50.00%
Transcript	ENST00000269571
Cosmic ID	COSM14065
Chr position(GRCh37)	chr17:37881332
Buffer	Tris-EDTA

Product Information
Intended Use	Research Use Only
Unit Size	1ug
Concentration	Download for COA
Purofication	Download for COA
DNA electrophoresis	Download for COA
Sanger sequencing
Storage	4℃
Expiry	36 months from the date of manufacture