hROR1/4T1 hROR1/4T1 hROR1/4T1
| I. Background | |||
| 受體激酶樣孤兒受體（Receptor Tyrosine Kinase-like orphan receptor，ROR）是 Ⅰ型受體激酶（receptor tyrosine kinase，RTK）家族中的成員，是一類膜受體，主要 包括 ROR1 和 ROR2。其中 ROR1 主要通過參與細胞內與細胞間信號傳導，實現調節細胞 代謝、增殖、凋亡、分化、遷移、轉移等功能。ROR1 在正常組織中（除了原腸胚時期） 表達量較低，但 ROR1 在多種腫瘤細胞高度表達，包括乳腺癌、卵巢癌、腎癌、肺腺細胞 癌、胃癌等實體瘤細胞以及某些血液腫瘤細胞。 | |||
| II. Introduction | |||
| Host Cell: | 4T1 | ||
| Expressed gene: | hROR1 | ||
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) | ||
| Freeze Medium: | 90% FBS+10% DMSO | ||
| Culture Medium: | RPMI-1640+10%FBS+2ug/ml puromycin | ||
| Mycoplasma Testing: | Negative | ||
| Storage: | Liquid nitrogen | ||
| III. Description of Host Cell Line | |||
| Organism: | Mouse | ||
| Tissue: | Mammary gland | ||
| Morphology: | Epithelial | ||
| Growth Properties: | Adherent | ||
| IV. Representative Data | |||
Figure 1. Recombinant hROR1/4T1 stably expressing ROR1. | |||
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