PGLYRP1 Target Cell
| I. Background | |
肽聚糖識別蛋白 1（Peptidoglycan Recognition Protein 1），也被稱為 TAG7、PGRP-S， 在昆蟲和哺乳動物體內所發現的一種先天性免疫激活蛋白，可介導抗菌作用和先天免疫反 應。PGLYRP1 蛋白在免疫細胞中高度表達，如中性粒細胞、巨噬細胞和嗜酸性粒細胞，并 與多種炎癥有關，包括類風濕性關節炎、氣道炎癥，冠狀動脈疾病或者哮喘口腔炎癥和癌 癥。 | |
| II. Description | |
PGLYRP1 Target Cell 作為 TREM1 Effector Reporter Cell 的靶細胞，很好的模擬了體內 TREM1 的信號轉導過程，原理見下圖所示。
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| III. Introduction | |
| Expressed gene: | PGLYRP1 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+600 μg/ml Hygromycin B |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| IV. Representative Data | |
Figure 1. Blocking of PGLYRP1 (plus 1ug/ml PGN)induced TREM1 Effector Reporter Cell(C33) Activity by TREM1 Blokcing Ab with PGLYRP1 Target Cell . | |
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