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TRAIL Polyclonal Antibody
宿主: Polyclonal, Rabbit,IgG
反應性: Human;Rat;Mouse;
應用: WB;IHC;IF;ELISA

TRAIL Polyclonal Antibody

抗體，也叫免疫球蛋白（Ig），是一種能特異性結合抗原的糖蛋白，而抗原是在易感染動物體內引發抗體產生的物質。在體內，抗體是由于外源性分子的侵襲而產生的。抗體以一個或者多個Y字形單體存在，每個Y字形單體由4條多肽鏈組成，包含兩條相同的重鏈和兩條相同的輕鏈。輕鏈和重鏈是根據它們的分子量大小來命名的。Y字形結構的頂端是可變區，為抗原結合部位。任何一個抗體的輕鏈都可以分為κ或λ型（基于小分子多肽結構上的差異），每一個抗體的重鏈則決定了它的類或型。

產品詳情

TRAIL Polyclonal Antibody detects endogenous levels of TRAIL protein.

免疫原詳細信息

The antiserum was produced against synthesized peptide derived from the Internal region of human TNFSF10. AA range:31-80

相關試劑

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

背景

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

天津俊達生物科技有限公司，是從事實驗室耗材銷售的現代化生物科技企業，公司本著“誠信為本，互利共贏"的核心價值觀，秉承“以市場為導向，提供服務"的宗旨為各大院校、科研單位、第三方實驗室檢測機構等提供的產品和服務。目前公司主要經營分子生物學、細胞生物學、免疫學等生物學產品，多種實驗室耗材歡迎垂詢！

備注：圖片僅供參考。僅供科研，不可用于臨床。

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天津俊達生物科技有限公司

天津俊達生物科技有限公司

TRAIL Polyclonal Antibody

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