Resiniferatoxin

MCE 國(guó)際站：Resiniferatoxin

CAS：57444-62-9

品牌：MedChemExpress (MCE)

存儲(chǔ)條件：-20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

生物活性：Resiniferatoxin ((+)-Resiniferatoxin)，是一種選擇性 TRPV1 受體激動(dòng)劑，能夠從 Euphorbia resinifera 植物中提取得到。在動(dòng)物模型中，Resiniferatoxin 能夠在相當(dāng)長(zhǎng)的一段時(shí)間內(nèi)消除 TRPV1+ 初級(jí)感覺傳入和鈍性心臟交感傳入反射。

體外：Resiniferatoxin 導(dǎo)致通道開放時(shí)間延長(zhǎng)和鈣內(nèi)流，從而導(dǎo)致對(duì) TRPV1 陽(yáng)性疼痛纖維或細(xì)胞體的細(xì)胞毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.

體內(nèi)：Resiniferatoxin (2 μg/10 μl；鞘內(nèi)注射到 T2/T3 間隙；冠狀動(dòng)脈閉塞后 4 周誘導(dǎo)大鼠心力衰竭) 顯著和選擇性地消除背角的傳入標(biāo)記物表達(dá) (TRPV1 和降鈣素基因相關(guān)肽) 并減少過度激活的 CSNA。Resiniferatoxin 顯著逆轉(zhuǎn)動(dòng)作電位持續(xù)時(shí)間 (APD) 和 APD 交替的延長(zhǎng)，降低室性心律失常的誘發(fā)性[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Clinical Trial

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研究領(lǐng)域：Membrane Transporter/Ion Channel  |  Neuronal Signaling

作用靶點(diǎn)：TRP Channel

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參考文獻(xiàn)：

[1]. Brown DC. Resiniferatoxin: The Evolution of the "Molecular Scalpel" for Chronic Pain Relief. Pharmaceuticals (Basel). 2016;9(3):47. Published 2016 Aug 11.[2]. Wu Y, et al. Resiniferatoxin reduces ventricular arrhythmias in heart failure via selectively blunting cardiac sympathetic afferent projection into spinal cord in rats. Eur J Pharmacol. 2020;867:172836.