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| 產品英文名稱 | Human IGF1 Protein |
| 產品中文名稱 | 樣生長因子1（IGFI） |
| 別名 | Long R3 IGF-I; Insulin-like growth factor I; MGF; Somatomedin-C; IBP1 |
| 標簽 | 無標簽 |
| 表達宿主 | 大腸桿菌 |
| 種屬 | 人 |
| 序列 | 氨基酸序列來源于：樣生長因子1（IGFI) (P05019-1) (Gly49-Ala118) 表達的蛋白片段。 |
| 活性 | 通過其誘導MCF-7細胞增殖的能力來測定。該效應的ED50為76.41 ng/mL。 |
| 蛋白長度 | 樣生長因子1（IGFI） 由71個氨基酸組成，預測分子量為7.8 KD。 |
| 純度 | > 99% ，使用SDS-PAGE檢測 |
| 特點&優勢 | 通過LAL法測定，每微克蛋白里內毒素含量<1.0> |
| 產品形式 | 凍干粉，凍干緩沖液為無菌的20 mM Tris，150 mM NaCl，pH 7.4。 |
| 基因ID | 3479 |
| 蛋白序列鏈接 | /uniprotkb/P05019/entry#P05019-1 |
| 使用中注意事項 | 開蓋使用前，請先離心。本產品為凍干粉，推薦用該產品配套的Reconstitution Buffer進行復溶，且濃度不低于100 µg/mL。客戶可根據后續的實驗需求，進行進一步的稀釋。 |
| 保存建議 | 本產品為凍干粉形式，建議：將凍干粉產品保存于-20℃以下的干燥環境中。本產品溶解之后，可在4℃保存2-7天，長期使用請置于-20℃以下。為長期保存，推薦添加載體蛋白（0.1% HAS/BSA或13%FBS），并酌情分裝保存，避免反復凍融。 |
| 運輸條件 | 冰袋運輸（藍冰） |
| 警告 | 本文列出的產品僅供研究使用，不適用于人類或臨床診斷。我們產品所推薦應用，不是建議使用我們的產品去違反任何或許可證。對于使用本產品可能發生的侵權或其他違規行為，我們不承擔任何責任。 |
| 背景 | IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ), and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also about enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness, and mental retardation. |
Fig.Human IGF1 Protein
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