目錄:杭州斯達特生物科技有限公司>>抗體/抗原>>流式抗體>> S0B1631APC Mouse Anti-Human CD45 Antibody (S-839-3)
CD45 is a member of the protein tyrosine phosphatase （PTP） family. CD45 is a type I transmembrane protein that is present in various isoforms on all differentiated hematopoietic cells （except erythrocytes and plasma cells）. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes via its extracellular domain （a form of co-stimulation）, or by activating various Src family kinases required for the antigen receptor signaling via its cytoplasmic domain. CD45 also suppresses JAK kinases, and so functions as a negative regulator of cytokine receptor signaling.
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