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CD62L, also known as L-selectin, is a type-I transmembrane glycoprotein and cell adhesion molecule belonging to the selectin family, primarily expressed on the surface of leukocytes, including T cells, B cells, and natural killer cells. It plays a crucial role in leukocyte homing and immune cell localization by mediating the initial rolling and adhesion of white blood cells to endothelial cells during inflammation. CD62L is also a marker for central memory T cells, which have a higher expression level of this molecule, allowing them to quickly respond to antigen re-exposure. Additionally, CD62L is involved in the regulation of immune cell distribution in tissues, impacting the strength and duration of immune responses. In cancer therapy, manipulating CD62L expression can enhance T cell infiltration into the tumor microenvironment, improving the efficacy of immunotherapy.