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T-cell surface glycoprotein CD3 gamma chain is a protein that in humans is encoded by the CD3G gene. T cell antigen receptor （TCR） is associated on the T cell surface with a complex of protein called CD3. CD3G （gamma chain） is one of the four peptides （gamma, delta, epsilon and zeta） that form CD3. Defects in CD3G are associated with T cell immunodeficiency.