The Nectin cell adhesion molecule （Nectin） family members are Ca2+?independent immunoglobulin?like cellular adhesion molecules （including Nectins 1?4）, involved in cell adhesion via homophilic/heterophilic interplay. In addition, the Nectin family plays a significant role in enhancing cellular viability and movement ability. In contrast to enrichment of Nectins 1?3 in normal tissues, Nectin?4 is particularly overexpressed in a number of tumor types, including breast, lung, urothelial, colorectal, pancreatic and ovarian cancer. Moreover, the upregulation of Nectin?4 is an independent biomarker for overall survival in numerous cancer types [PMID: 34664682].