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目錄:杭州斯達特生物科技有限公司>>抗體/抗原>>偶聯(lián)抗體>> S0B1556CD117 Recombinant Rabbit mAb (Alexa Fluor? 594 Conjugate) (S-125-51)

CD117 Recombinant Rabbit mAb (Alexa Fluor? 594 Conjugate) (S-125-51)
  • CD117 Recombinant Rabbit mAb (Alexa Fluor? 594 Conjugate) (S-125-51)
參考價 458
具體成交價以合同協(xié)議為準
參考價 458
具體成交價以合同協(xié)議為準
  • 品牌 Starter/斯達特
  • 型號 S0B1556
  • 廠商性質(zhì) 生產(chǎn)商
  • 所在地 杭州市
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更新時間:2025-07-14 14:38:39瀏覽次數(shù):39評價

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CD117 Recombinant Rabbit mAb (Alexa Fluor? 594 Conjugate) (S-125-51)

Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR). Altered forms of this receptor may be associated with some types of cancer. KIT is a receptor tyrosine kinase type III, which binds to stem cell factor, also known as "steel factor" or "c-kit ligand" and expressed on the surface of hematopoietic stem cells as well as other cell types. When this receptor binds to stem cell factor (SCF) it forms a dimer that activates its intrinsic tyrosine kinase activity, that in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell. After activation, the receptor is ubiquitinated to mark it for transport to a lysosome and eventual destruction. Signaling through KIT plays a role in cell survival, proliferation, and differentiation. For instance, KIT signaling is required for melanocyte survival, and it is also involved in haematopoiesis and gametogenesis.

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