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M-MLV （H-） Reverse Transcriptase is an RNA-dependent DNA polymerase with reduced RNase H activity. This enzyme can use RNA （when synthesizing cDNA） or single-stranded DNA as a template and initiate the synthesis of a complementary DNA strand from a primer. M-MLV（H-） reverse transcriptase has no 3′ → 5′ exonuclease activity. It can be used to synthesize first strand cDNA more efficient than the wild type M-MuLV。