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 文獻名：Photoswitchable Janus glycodendrimer micelles as m*lent inhibitors of LecA and LecB from Pseudomonas aeruginosa 

 

作者：Yingxue Hu^a, Ghamdan Beshr^b,c, Christopher J.Garvey^d, Rico F.Tabor^a, Alexander Titz^b,c, Brendan L.Wilkinson^e 

^a    School of Chemistry, Monash University, Victoria 3800, Australia

^b    Chemical Biology of Carbohydrates, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), D-66123 Saarbrücken, Germany

^c    Deutsches Zentrum für Infektionsforschung, Standort Hannover, Braunschweig, Germany

^d    Australian Centre for Neutron scattering, ANSTO, Lucas Heights, New South Wales 2234, Australia

^e    School of Science and Technology, the University of New England, New South Wales 2351, Australia

 

摘要：The first example of the self-assembly and lectin binding properties of photoswitchable glycodendrimer micelles is reported. Light-addressable micelles were assembled from a library of 12 amphiphilic Janus glycodendrimers composed of variable carbohydrate head groups and hydrophobic tail groups linked to an azobenzene core. Spontaneous association in water gave cylindrical micelles with uniform size distribution as determined by dynamic light scattering (DLS) and small angle neutron scattering (SANS). Trans-cis photoisomerization of the azobenzene dendrimer core was used to probe the self-assembly behaviour and lectin binding properties of cylindrical micelles, revealing moderate-to-potent inhibition of lectins LecA and LecB from Pseudomonas aeruginosa.