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利格列汀雜質對照品全套有哪些
深圳遠揚化學技術有限公司可提供利格列汀坦項目申報所用全套雜質， 隨貨提供CoA證書，HNMR，MS，HPLC圖譜，純度符合申報要求，現貨庫存，交貨及時，并可根據客戶提供結構式進行利格列汀雜質定制合成。
利格列汀化合物是商品名為利格列汀片藥物的主要成分，化學名為8-[（3R）-3-氨基-1-哌啶基]-7-(2-丁炔基-1)-3,7-二氫-3-甲基-1-[（4-甲基-2-喹唑啉基）甲基]-1H-嘌呤-2,6-二酮；臨床上該化合物合成的藥物是屬于一種新的有效的選擇性二肽基肽酶-4（DPP-4）抑制劑，可用于治療2型糖尿病。
藥理作用：利格列汀是二肽基肽酶4（DPP-4）抑制劑，DPP-4能夠降解腸促胰島素激素樣多肽-1（GLP-1）以及葡萄糖依賴性促胰島素多肽（GIP）。利格列汀能夠升高活性腸促胰島素激素的濃度，以葡萄糖依賴性的方式刺激胰島素釋放，降低循環中的胰高血糖素水平。
這兩種腸促胰島素激素都參與了葡萄糖穩態的生理調節。一天中腸促胰島素分泌維持較低的基礎水平，進餐后立即升高。在葡萄糖水平正常或升高的條件下，GLP-1和GIP能增加胰腺β-細胞胰島素的生物合成和分泌。此外，GLP-1還能減少胰腺α細胞的胰高血糖素分泌，肝葡萄糖排出量減少。
利格列汀雜質對照品全套有哪些
| 利格列汀 CAS號：668270-12-0 | Linagliptin |
| 利格列汀雜質1 | 7-(but-2-yn-1-yl)-8-((2-hydroxyethyl)amino)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione |
| 利格列汀雜質2 | 2-((R)-3-aminopiperidine-1-carbonyl)-N-((R)-1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)benzamide |
| 利格列汀雜質3 CAS號：886588-63-2 | N-Phthalimide-linagliptin |
| 利格列汀雜質4 CAS號：1638744-06-5 | Linagliptin Impurity S |
| 利格列汀雜質5 | N1,N2-bis((R)-1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)phthalamide |
| 利格列汀雜質6 | (R)-2-((1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamoyl)benzoic acid |
| 利格列汀雜質7 | Linagliptin Diene Impurity |
| 利格列汀雜質8 | (Z)-8-bromo-7-(3-bromobut-2-en-1-yl)-3-methyl-3,7-dihydro-1H-purine-2,6-dione |
| 利格列汀雜質9 | 8-bromo-1,7-di(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H,7H)-dione |
| 利格列汀雜質10 | (R)-tert-butyl (1-(1,7-di(but-2-yn-1-yl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamate |
| 利格列汀雜質11 | (R)-8-(3-aminopiperidin-1-yl)-1,7-di(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H,7H)-dione |
| 利格列汀雜質12 | 8-bromo-3-methyl-7-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione |
| 利格列汀雜質13 | (R)-tert-butyl (1-(3-methyl-7-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamate |
| 利格列汀雜質14 | (R)-8-(3-aminopiperidin-1-yl)-3-methyl-7-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione |
| 利格列汀雜質15 CAS號：1446263-38-2 | (R)-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-8-(piperidin-3-ylamino)-3,7-dihydro-1H-purine-2,6-dione |
| 利格列汀雜質16 CAS號：1803079-49-3 | (R)-N-(1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)-2,2,2-trifluoroacetamide |
| 利格列汀雜質17 CAS號： 668270-11-9 | (S)-Linagliptin |
| 利格列汀雜質18 | 7-(but-2-yn-1-yl)-8-(dimethylamino)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione |
| 利格列汀雜質19 | N-(2-acetylphenyl)-2-(8-bromo-7-(but-2-yn-1-yl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)acetamide |
| 利格列汀雜質20 | (R)-tert-butyl (1-(1-(2-((2-acetylphenyl)amino)-2-oxoethyl)-7-(but-2-yn-1-yl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamate |
| 利格列汀雜質21 | (R)-N-(2-acetylphenyl)-2-(8-(3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-1-yl)acetamide |
| 利格列汀雜質22 | (R)-tert-butyl (1-(7-(but-2-yn-1-yl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamate |
| 利格列汀雜質23 | (R)-8-(3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H,7H)-dione |
| 利格列汀雜質24 | (S)-tert-butyl (1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamate |
| 利格列汀雜質25 | (R)-7-(but-2-yn-1-yl)-8-(3-((7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)amino)piperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione |
| 利格列汀雜質26 | Linagliptin Acetamide |
| 利格列汀雜質27 | 8-bromo-7-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione |
| 利格列汀雜質28 | (R)-8-(3-aminopiperidin-1-yl)-7-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione |
| 利格列汀雜質29 | (R)-1-((4-methylquinazolin-2-yl)methyl)piperidin-3-amine |
| 利格列汀雜質30 | 1-(2-(((4-methylquinazolin-2-yl)methyl)amino)phenyl)ethanone |
| 利格列汀雜質31 | 8-((2-acetylphenyl)amino)-7-(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H,7H)-dione |
| 利格列汀雜質32 | 8-((2-acetylphenyl)amino)-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione |
| 利格列汀雜質33 CAS號：93703-24-3 | 8-bromo-3-methyl-1H-purine-2,6(3H,7H)-dione |
| 利格列汀雜質34 | 7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione |
| 利格列汀雜質35 | tert-butyl (7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)(piperidin-4-yl)carbamate |
| 利格列汀雜質36 | (S)-1-(1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)urea |
| 利格列汀雜質37 | (S)-N-(1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)acetamide |
| 利格列汀雜質38 | 8-((R)-3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-1-((4-((S)-2-(((R)-1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)amino)propyl)quinazolin-2-yl)methyl)-3-methyl-1H-purine-2,6(3H,7H)-dione |
| 利格列汀雜質39 | 7-(but-2-yn-1-yl)-3-methyl-8-(methylamino)-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione |
| 利格列汀雜質40 | 8-ethoxy-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione |
| 利格列汀雜質41 | 8-((R)-3-aminopiperidin-1-yl)-7-((Z)-3-(((R)-1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)amino)but-2-en-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,7H)-dione |
| 利格列汀雜質42 | 8-bromo-3-methyl-1,7-bis((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione |
| 利格列汀雜質43 CAS號：88203-04-7 | 2-((2-acetylphenyl)amino)acetonitrile |
| 利格列汀雜質44 CAS號：666816-98-4 | 8-bromo-9-(but-2-yn-1-yl)-3-methyl-1H-purine-2,6(3H,9H)-dione |
| 利格列汀雜質45 | (R)-9-(but-2-yn-1-yl)-8-(3-(1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,9H)-dione |
| 利格列汀雜質46 | 8-bromo-9-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,9H)-dione |
| 利格列汀雜質47 | (R)-8-(3-aminopiperidin-1-yl)-9-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-1H-purine-2,6(3H,9H)-dione |
| 利格列汀雜質48 | 8-bromo-7-(but-2-yn-1-yl)-3-methyl-6-((4-methylquinazolin-2-yl)methoxy)-3,7-dihydro-2H-purin-2-one |
| 利格列汀雜質49 | 8-bromo-7-(but-2-yn-1-yl)-3-methyl-2-((4-methylquinazolin-2-yl)methoxy)-3H-purin-6(7H)-one |
| 利格列汀雜質50 | (R)-2-(1-(7-(but-2-yn-1-yl)-3-methyl-6-((4-methylquinazolin-2-yl)methoxy)-2-oxo-3,7-dihydro-2H-purin-8-yl)piperidin-3-yl)isoindoline-1,3-dione |
| 利格列汀雜質51 | (R)-2-(1-(7-(but-2-yn-1-yl)-3-methyl-2-((4-methylquinazolin-2-yl)methoxy)-6-oxo-6,7-dihydro-3H-purin-8-yl)piperidin-3-yl)isoindoline-1,3-dione |
| 利格列汀雜質52 | (R)-8-(3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-6-((4-methylquinazolin-2-yl)methoxy)-3,7-dihydro-2H-purin-2-one |
| 利格列汀雜質53 | (R)-8-(3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-2-((4-methylquinazolin-2-yl)methoxy)-3H-purin-6(7H)-one |
| 利格列汀雜質54 | (R)-8-(3-aminopiperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-7-((4-methylquinolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione |
| 利格列汀雜質55 | N-(2-acetylphenyl)-2-bromoacetamide |
| 利格列汀雜質56 | tert-butyl ((3R)-1-(7-(but-2-yn-1-yl)-3-methyl-2-((4-methylquinazolin-2-yl)methoxy)-6-oxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)carbamate |
| 利格列汀雜質57 | 8-((R)-3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-2-((4-methylquinazolin-2-yl)methoxy)-1,2,3,7-tetrahydro-6H-purin-6-one |
| 利格列汀雜質58 | tert-butyl (R)-(1-(7-(but-2-yn-1-yl)-3-methyl-6-((4-methylquinazolin-2-yl)methoxy)-2-oxo-3,7-dihydro-2H-purin-8-yl)piperidin-3-yl)carbamate |
| 利格列汀雜質59 | (R)-8-(3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-6-((4-methylquinazolin-2-yl)methoxy)-3,7-dihydro-2H-purin-2-one |
| 利格列汀雜質60 | (R)-7-(but-2-yn-1-yl)-8-(3-hydroxypiperidin-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione |
| 利格列汀雜質61 | (R)-1-(1-(7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)piperidin-3-yl)urea |
| 利格列汀雜質62 | 8-bromo-9-(but-2-yn-1-yl)-3-methyl-3,9-dihydro-1H-purine-2,6-dione |
深圳遠揚化學技術有限公司可現貨供應各種雜質對照品，醫藥標準品：噁拉戈利雜質，鄰乙酰水楊酸雜質，頭孢唑啉鈉雜質，氯美扎酮雜質，巴多昔芬雜質，美羅培南雜質，頭孢丙烯雜質，乙酰氯芬酸雜質，尼美舒利雜質，保泰松雜質，沃拉帕贊雜質，雷洛昔芬雜質，甲氧氯普胺雜質，匹多莫德雜質，非洛地平雜質，度他雄胺雜質，甲巰咪唑雜質，達格列凈雜質，依美斯汀雜質，帕羅西汀雜質，阿法替尼雜質，克唑替尼雜質，阿莫沙平雜質，貝那普利雜質，阿折地平雜質，伐昔洛韋雜質，伊潘立酮雜質，替莫唑胺雜質，喹硫平雜質，阿莫西林雜質，左旋多巴雜質，來那替尼雜質，普瑞巴林雜質，馬來酸桂哌齊特雜質等，圖譜證書齊全，純度保證。
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