文獻名：Gadolinium-chelate functionalized magnetic CuFeSe2 ternary nanocrystals for T1-T2 dual MRI and CT imaging in vitro and in vivo

作者： Lu-Yao Lai^5,1, Ying Jiang^5,2, Guang-Ping Su¹, Min Wu³, Xiao-Fei Lu², Shao-Zhi Fu⁴, Lu Yang^6,1 and Jian Shu^6,1

¹ Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China

² Department of Radiology, The 2nd Affiliated Hospital of Chengdu Medical College Nuclear Industry 416 Hospital, Chengdu, Sichuan, People's Republic of China

³ Department of Radiology, Chongqing Traditional Chinese Medicine Hospital, Chongqing, People's Republic of China

⁴ Department of oncology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People's Republic of China

摘要：CuFeSe2 nanomaterial with high thermal conversion efficiency, well superparamagnetism, effective x-ray attenuation ability, multifunctional groups and excellent biocompatibility is beneficial to the construction of multimodal imaging probes which can combine various imaging modes to provide a synergistic advantage over a single imaging mode. This study aimed to develop a novel multimodal nanocontrast agent CuFeSe2@diethylenetriaminepentaacetic acid (DTPA)-Gd to obtain imaging information with high specificity, high sensitivity and high contrast. The morphology and physical characteristics of CuFeSe2@DTPA-Gd were detected by transmission electron microscope, scanning electron microscope, x-ray single crystal diffraction, vibrating sample magnetometer and fourier transform infrared spectrometer. The toxicity of CuFeSe2@DTPA-Gd in vivo was evaluated by hematoxylin-eosin staining. The imaging capability of CuFeSe2@DTPA-Gd in vitro and in vivo was evaluated by magnetic resonance imaging (MRI) and computed tomography (CT). This study successfully prepared nanoparticles CuFeSe2@DTPA-Gd, and experimental results in this study demonstrated CuFeSe2@DTPA-Gd is expected to be a useful CT and MRI T1-weighted imaging/T2-weighted imaging three-modal contrast agent in clinic.

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